abstract：:Surface functionalization has become of paramount importance and is considered a fundamental tool for the development and design of countless devices and engineered systems for key technological areas in biomedical, biotechnological and environmental applications. In this review, surface functionalization strategies f...

journal_title：Acta biomaterialia

authors： Treccani L,Yvonne Klein T,Meder F,Pardun K,Rezwan K

更新日期：2013-07-01 00:00:00

abstract：:Polymeric fibrous scaffolds have been considered as replacements for load-bearing soft tissues, because of their ability to mimic the microstructure of natural tissues. Poor toughness of fibrous materials results in failure, which is an issue of importance to both engineering and medical practice. The toughness of fib...

journal_title：Acta biomaterialia

authors： Koh CT,Strange DG,Tonsomboon K,Oyen ML

更新日期：2013-07-01 00:00:00

abstract：:To search for potential non-viral nucleic acids carriers, a series of novel cationic polymers, multi-armed poly(aspartate-graft-oligoethylenimine) (MP-g-OEI) copolymers were designed and synthesized by grafting different types of oligoethylenimine (OEI) to a multi-armed poly(l-aspartic acid) backbone. The as-synthesiz...

journal_title：Acta biomaterialia

authors： Dong X,Lin L,Chen J,Tian H,Xiao C,Guo Z,Li Y,Wei Y,Chen X

更新日期：2013-06-01 00:00:00

abstract：:During the past two decades, research on ceramic scaffolds for bone regeneration has progressed rapidly; however, currently available porous scaffolds remain unsuitable for load-bearing applications. The key to success is to apply microstructural design strategies to develop ceramic scaffolds with mechanical propertie...

journal_title：Acta biomaterialia

authors： Roohani-Esfahani SI,Dunstan CR,Li JJ,Lu Z,Davies B,Pearce S,Field J,Williams R,Zreiqat H

更新日期：2013-06-01 00:00:00

abstract：:Gelatin and alginate derivatives possessing phenolic hydroxyl moieties (gelatin-Ph and Alg-Ph) were dissolved in aqueous solution and conjugated via horseradish peroxidase-catalyzed crosslinking, resulting in hydrogelation. The objective of creating the hydrogels was to prepare cell sheets and spherical tissues wrappe...

journal_title：Acta biomaterialia

authors： Liu Y,Sakai S,Taya M

更新日期：2013-05-01 00:00:00

abstract：:Human enamel has been found to be a coating with excellent mechanical performance, and has undergone extensive investigation and discussion. However, most of the reported studies consider the enamel as a homogeneous anisotropic biocomposite. The current study illustrated the graded properties of the biocomposite from ...

journal_title：Acta biomaterialia

authors： He LH,Yin ZH,van Vuuren LJ,Carter EA,Liang XW

更新日期：2013-05-01 00:00:00

abstract：:Implantation of biomaterials into the body elicits a material-dependent inflammatory response called the foreign body reaction (FBR). Macrophages play a pivotal role in the FBR by orchestrating the pro-inflammatory microenvironment around the biomaterials by secreting cytokines, chemokines and growth factors. When the...

journal_title：Acta biomaterialia

authors： van Putten SM,Ploeger DT,Popa ER,Bank RA

更新日期：2013-05-01 00:00:00

abstract：:The use of paper-based test platforms in cell culture experiments is demonstrated. The arrays used for two-dimensional cell cultures were prepared by printing patterned structures on a paper substrate using a hydrophobic polydimethylsiloxane (PDMS) ink. The non-printed, PDMS-free areas formed the array for the cell gr...

journal_title：Acta biomaterialia

authors： Juvonen H,Määttänen A,Laurén P,Ihalainen P,Urtti A,Yliperttula M,Peltonen J

更新日期：2013-05-01 00:00:00

abstract：:Introducing nanoroughness on various biomaterials has been shown to profoundly effect cell-material interactions. Similarly, physical forces act on a diverse array of cells and tissues. Particularly in bone, the tissue experiences compressive or tensile forces resulting in fluid shear stress. The current study aimed t...

journal_title：Acta biomaterialia

authors： Prodanov L,Semeins CM,van Loon JJ,te Riet J,Jansen JA,Klein-Nulend J,Walboomers XF

更新日期：2013-05-01 00:00:00

abstract：:Turtle shell is a multi-scale bio-composite in which the components are arranged in various spatial patterns, leading to an unusually strong and durable structure. The keratin-coated dorsal shell, termed the carapace, exhibits a flat bone, sandwich-like structure made up of two exterior cortices enclosing a cancellous...

journal_title：Acta biomaterialia

authors： Achrai B,Wagner HD

更新日期：2013-04-01 00:00:00

abstract：:Slow protein release from amyloidal materials is a molecular platform used by nature to control protein hormone secretion in the endocrine system. The molecular mechanics of the sustained protein release from amyloids remains essentially unexplored. Inclusion bodies (IBs) are natural amyloids that occur as discrete pr...

journal_title：Acta biomaterialia

authors： Cano-Garrido O,Rodríguez-Carmona E,Díez-Gil C,Vázquez E,Elizondo E,Cubarsi R,Seras-Franzoso J,Corchero JL,Rinas U,Ratera I,Ventosa N,Veciana J,Villaverde A,García-Fruitós E

更新日期：2013-04-01 00:00:00

abstract：:The preparation of scaffolds to facilitate the replacement of damaged tissues and organs by means of tissue engineering has been much investigated. The key properties of the biomaterials used to prepare such scaffolds include biodegradability, biocompatibility and a well-defined three-dimensional 3-Dpore network struc...

journal_title：Acta biomaterialia

authors： Ronca A,Ambrosio L,Grijpma DW

更新日期：2013-04-01 00:00:00

abstract：:Three protease-resistant bioorganic 304 stainless steel surfaces were created through the reaction of synthetic peptides consisting of the D-enantiomeric isomer (D-K122-4), the retro-inverso D-enantiomeric isomer (RI-K122-4), and a combination of the two peptides (D+RI) of the Pseudomonas aeruginosa PilA receptor bind...

journal_title：Acta biomaterialia

authors： Davis EM,Li D,Shahrooei M,Yu B,Muruve D,Irvin RT

更新日期：2013-04-01 00:00:00

abstract：:Calcium phosphate cements (CPCs) are highly valuable materials for filling bone defects and bone augmentation by minimal invasive application via percutaneous injection. In the present study some key features were significantly improved by developing a novel injectable ready-to-use calcium phosphate cement based on wa...

journal_title：Acta biomaterialia

authors： Heinemann S,Rössler S,Lemm M,Ruhnow M,Nies B

更新日期：2013-04-01 00:00:00

abstract：:The combination of hydrogels and calcium phosphate particles is emerging as a well-established trend for bone substitutes. Besides acting as binders for the inorganic phase, hydrogels within these hybrid materials can modulate cell colonization physically and biologically. The influence of hydrogels on the healing pro...

journal_title：Acta biomaterialia

authors： D'Este M,Eglin D

更新日期：2013-03-01 00:00:00

abstract：:The rationale for the use of polymer-ceramic composites for bone regeneration stems from the natural composition of bone, with collagen type I and biological apatite as the main organic and inorganic constituents, respectively. In the present study composite materials of PolyActive™ (PA), a poly(ethylene oxide terepht...

journal_title：Acta biomaterialia

authors： Nandakumar A,Cruz C,Mentink A,Tahmasebi Birgani Z,Moroni L,van Blitterswijk C,Habibovic P

更新日期：2013-03-01 00:00:00

abstract：:In a previous paper we presented a theoretical framework to describe tissue growth in confined geometries based on the work of Ambrosi and Guillou [Ambrosi D, Guillou A. Growth and dissipation in biological tissues. Cont Mech Thermodyn 2007;19:245-51]. A thermodynamically consistent eigenstrain rate for growth was der...

journal_title：Acta biomaterialia

authors： Gamsjäger E,Bidan CM,Fischer FD,Fratzl P,Dunlop JW

更新日期：2013-03-01 00:00:00

abstract：:The objective was to evaluate the presence and distribution of the lubricating and anti-adhesion glycoprotein lubricin and cells containing the contractile isoform smooth muscle α-actin (SMA) in pseudomembranes around loose hip prostheses. Periprosthetic tissue was obtained at revision arthroplasty of eight aseptic, l...

journal_title：Acta biomaterialia

authors： Cheriyan T,Ready JE,Brick GW,Martin SD,Martin TL,Schmid TM,Padera RF,Spector M

更新日期：2013-03-01 00:00:00

abstract：:Delivery of vaccine antigens with an appropriate adjuvant can trigger potential immune responses against cancer leading to reduced tumor growth and improved survival. In this study, various formulations of a bioerodible amphiphilic polyanhydride copolymer based on 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) and ...

journal_title：Acta biomaterialia

authors： Joshi VB,Geary SM,Carrillo-Conde BR,Narasimhan B,Salem AK

更新日期：2013-03-01 00:00:00

abstract：:Collagen, collagen/hyaluronic acid (HA) and collagen/HA/chitosan (CS) sponges loaded with epigallocatechin gallate (EGCG), catechin (CAT) and gallic acid (GA) were developed and evaluated as active chronic wound dressings. Their physico-mechanical properties, biostability, biocompatibility and ability to inhibit in vi...

journal_title：Acta biomaterialia

authors： Francesko A,Soares da Costa D,Reis RL,Pashkuleva I,Tzanov T

更新日期：2013-02-01 00:00:00

abstract：:Currently there is no material that can be used as a long-term vitreous substitute, and this remains an unmet clinical need in ophthalmology. In this study, we developed an injectable, in situ chemically crosslinked hydrogel system and evaluated it in a rabbit model. The system consisted of two components, both based ...

journal_title：Acta biomaterialia

authors： Tao Y,Tong X,Zhang Y,Lai J,Huang Y,Jiang YR,Guo BH

更新日期：2013-02-01 00:00:00

abstract：:Titanium oxide (TiO₂) scaffolds have previously been reported to exhibit very low mechanical strength. However, we have been able to produce a scaffold that features a high interconnectivity, a porosity of 91% and a compressive strength above 1.2 MPa. This study analyzed the in vivo performance of the porous TiO₂ scaf...

journal_title：Acta biomaterialia

authors： Haugen HJ,Monjo M,Rubert M,Verket A,Lyngstadaas SP,Ellingsen JE,Rønold HJ,Wohlfahrt JC

更新日期：2013-02-01 00:00:00

abstract：:Biodegradable PHBHHx (poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)) nanoparticles containing insulin phospholipid complex were loaded in chitosan-based thermosensitive hydrogels for long-term sustained and controlled delivery of insulin. The injectable hydrogels, prepared by adding β-glycerophosphate disodium salt (G...

journal_title：Acta biomaterialia

authors： Peng Q,Sun X,Gong T,Wu CY,Zhang T,Tan J,Zhang ZR

更新日期：2013-02-01 00:00:00

abstract：:Porcupines use their lightweight quills, which are strong enough to support significant compression and flexure loads, for defense. Hystrix, with long and thick quills, belongs to the family of Hystricidae (Old World porcupines), while Erethizon, with smaller quills, belongs to the Erethizontidae family (New World por...

journal_title：Acta biomaterialia

authors： Yang W,Chao C,McKittrick J

更新日期：2013-02-01 00:00:00

abstract：:Magnesium is an attractive material for use in biodegradable implants due to its low density, non-toxicity and mechanical properties similar to those of human tissue such as bone. Its biocompatibility makes it amenable for use in a wide range of applications from bone to cardiovascular implants. Here we investigated t...

journal_title：Acta biomaterialia

authors： Bornapour M,Muja N,Shum-Tim D,Cerruti M,Pekguleryuz M

更新日期：2013-02-01 00:00:00

abstract：:The use of biodegradable beta-tricalcium phosphate (β-TCP) scaffolds holds great promise for bone tissue engineering. However, the effects of β-TCP on bone and endothelial cells are not fully understood. This study aimed to investigate cell proliferation and differentiation of mono- or co-cultured human-bone-marrow-de...

journal_title：Acta biomaterialia

authors： Kang Y,Kim S,Fahrenholtz M,Khademhosseini A,Yang Y

更新日期：2013-01-01 00:00:00

abstract：:Nanocrystalline hydroxyapatite (HAp) and silicon-containing hydroxyapatite (SiHAp) particles were synthesized by a wet-chemical procedure and their heterogeneous structures involving a disordered phase were analyzed in detail by X-ray diffractometry (XRD), transmission electron microscopy (TEM), Fourier transform infr...

journal_title：Acta biomaterialia

authors： Hayakawa S,Kanaya T,Tsuru K,Shirosaki Y,Osaka A,Fujii E,Kawabata K,Gasqueres G,Bonhomme C,Babonneau F,Jäger C,Kleebe HJ

更新日期：2013-01-01 00:00:00

abstract：:A rapidly expanding literature broadly documents the impact of biophysical cues on cellular behaviors. In spite of increasing research efforts in this field, the underlying signaling processes are poorly understood. One of the candidate molecules for being involved in mechanotransduction is focal adhesion kinase (FAK)...

journal_title：Acta biomaterialia

authors： Dreier B,Raghunathan VK,Russell P,Murphy CJ

更新日期：2012-12-01 00:00:00

abstract：:The use of hybrid pH-sensitive micelles based mainly on the (PEO)(129)(P2VP)(43)(PCL)(17) ABC miktoarm star copolymer as potential triggered drug delivery systems was investigated. Co-micellization of this star copolymer with a second copolymer labeled by a targeting ligand, i.e. biotin, on the pH sensitive block (pol...

journal_title：Acta biomaterialia

authors： Cajot S,Van Butsele K,Paillard A,Passirani C,Garcion E,Benoit JP,Varshney SK,Jérôme C

更新日期：2012-12-01 00:00:00

abstract：:In order to expand the properties and applications of aliphatic absorbable polyesters, a new biodegradable block copolymer family, poly(ester amide)-b-poly(ε-caprolactone) (PEA-b-PCL), was synthesized and characterized. These copolymers were synthesized by first preparing l-phenylalanine-based poly(ester amide) macroi...

journal_title：Acta biomaterialia

authors： Wu J,Chu CC

更新日期：2012-12-01 00:00:00

abstract：:Mesoporous materials are of high interest as implant coatings to receive an enhanced osseointegration. In this study, titanium implants coated with mesoporous TiO(2) thin films have been evaluated both in vitro and in vivo. Material characterization showed that, with partly crystalline TiO(2) (anatase), long-range-ord...

journal_title：Acta biomaterialia

authors： Karlsson J,Jimbo R,Fathali HM,Schwartz-Filho HO,Hayashi M,Halvarsson M,Wennerberg A,Andersson M

更新日期：2012-12-01 00:00:00

abstract：:The aim of this study was to fabricate a fibrous scaffold that closely resembled the micro-structural architecture and mechanical properties of collagen fibres found in the anterior cruciate ligament (ACL). To achieve this aim, fibrous scaffolds were made by electrospinning L-lactide based polymers. L-Lactide was chos...

journal_title：Acta biomaterialia

authors： Surrao DC,Waldman SD,Amsden BG

更新日期：2012-11-01 00:00:00

abstract：:Thrombus formation, due to thrombin generation, is a major problem affecting blood-contacting medical devices. This work aimed to develop a new strategy to improve the hemocompatibility of such devices by the immobilization of a naturally occurring thrombin inhibitor into a nanostructured surface. Boophilin, a direct ...

journal_title：Acta biomaterialia

authors： Freitas SC,Cereija TB,Figueiredo AC,Osório H,Pereira PJ,Barbosa MA,Martins MC

更新日期：2012-11-01 00:00:00

abstract：:Flt1 peptide of GNQWFI is an antagonistic peptide for vascular endothelial growth factor receptor 1 (VEGFR1 or Flt1). In this work, Flt1 peptide-hyaluronate (HA) conjugates were successfully synthesized and the resulting micelle-like nanoparticles were exploited to encapsulate genistein, an inhibitor of tyrosine-speci...

journal_title：Acta biomaterialia

authors： Kim H,Choi JS,Kim KS,Yang JA,Joo CK,Hahn SK

更新日期：2012-11-01 00:00:00

abstract：:Sickle cell disease (SCD) is characterized by the abnormal deformation of red blood cells (RBCs) in the deoxygenated condition, as their elongated shape leads to compromised circulation. The pathophysiology of SCD is influenced by both the biomechanical properties of RBCs and their hemodynamic properties in the microv...

journal_title：Acta biomaterialia

authors： Byun H,Hillman TR,Higgins JM,Diez-Silva M,Peng Z,Dao M,Dasari RR,Suresh S,Park Y

更新日期：2012-11-01 00:00:00

abstract：:We investigated the in vivo therapeutic efficacy of an intra-articular controlled release system consisting of biodegradable poly(dl-lactic-co-glycolic acid) (PLGA) microparticles (MPs) encapsulating anti-inflammatory small interfering RNA (siRNA), together with branched poly(ethylenimine) (PEI) as a transfecting agen...

journal_title：Acta biomaterialia

authors： Mountziaris PM,Tzouanas SN,Sing DC,Kramer PR,Kasper FK,Mikos AG

更新日期：2012-10-01 00:00:00

abstract：:In order to evaluate the effect of the nanostructure of calcium phosphate ceramics on osteoinductive potential, porous biphasic calcium phosphate (BCP) ceramics with a nano- or submicron structure were prepared via microwave sintering and compared to conventional BCP ceramics. The selective protein adsorption of bovin...

journal_title：Acta biomaterialia

authors： Li B,Liao X,Zheng L,Zhu X,Wang Z,Fan H,Zhang X

更新日期：2012-10-01 00:00:00

abstract：:Localized controlled release of anti-fibrogenic factors can potentially prevent tissue fibrosis surrounding biomedical prostheses, such as vascular stents and breast implants. We have previously demonstrated that therapeutic intervention with topically applied stratifin in a rabbit ear fibrotic model not only prevents...

journal_title：Acta biomaterialia

authors： Rahmani-Neishaboor E,Hartwell R,Jalili R,Jackson J,Brown E,Ghahary A

更新日期：2012-10-01 00:00:00

abstract：:Human embryonic stem cells (hESC) are promising for use in regenerative medicine applications because of their strong proliferative ability and multilineage differentiation capability. To date there have been no reports on hESC seeding with calcium phosphate cement (CPC). The objective of this study was to investigate...

journal_title：Acta biomaterialia

authors： Tang M,Chen W,Weir MD,Thein-Han W,Xu HH

更新日期：2012-09-01 00:00:00

abstract：:This study demonstrated that the surface crystallinity of carbon nanostructures is an additional independent factor that should be considered for the inhibition of cancer proliferation without activating reactive oxygen species (ROS). In addition, cytotoxic evaluation of both proliferating cancer cells and fully diffe...

journal_title：Acta biomaterialia

authors： Choi J,Lee S,Wang W,Hahm SH,Han YS,Nam TH,Kim SH,Kang SS,Khang D

更新日期：2012-09-01 00:00:00